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Risk Factors for CKD Progression: Overview of Findings from the CRIC Study.

Department of Medicine, University of Illinois, Chicago, Illinois. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana. Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Nephrology Section, Boston University Medical Center, Boston, Massachusetts. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Division of Nephrology, Department of Medicine, University of Maryland, Baltimore, Maryland. Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio. Division of Nephrology, MetroHealth, Cleveland, Ohio. Department of Medicine, The University of Chicago, Chicago, Illinois. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Clinical journal of the American Society of Nephrology : CJASN. 2021;(4):648-659
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Abstract

The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.

Methodological quality

Publication Type : Multicenter Study ; Review

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